Titled, with mordant irony, "The Earthly Paradise", in England, but had its title changed to "To the Indies" for the United States audience. I read this book when I was in high school, but found it too depressing to read now. Like all Forester books, it's an excellent novel.

http://fireandsword.blogspot.com/2006/12/to-indies-by-c.html

Though he is better known for his tales of Horatio Hornblower, C.S. Forester was capable of evoking eras other than the Napoleonic and attitudes other than upper-class England’s. In To the Indies Forester tells the tale of Columbus’ next-to-last voyage to the Indies.