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Gene Machine: The Race to Decipher the Secrets of the Ribosome (2018)

por Venki Ramakrishnan

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"The co-recipient of the 2009 Nobel Prize in Chemistry discusses his critical research on the ribosome, a molecular machine that actually forces DNA into action, turning genetic code into functioning proteins that create life"--Source of summary not specified. "Everyone has heard of DNA--the molecule that seems to hold the secrets to all life. But by itself, DNA is little more than a blueprint for life, resting inertly within our cells. Hardly anyone, however, has heard of a ribosome. Ribosomes are enormous molecular machines, even more ancient than DNA, that translate the information in our genes into proteins. Those proteins in turn make up much of our bodies and catalyze thousands of processes within our cells. A ribosome, in short, is a machine no cell can do without. And until quite recently, how that machine worked was a mystery. Gene Machine is an insider account of the Nobel Prize--winning race to uncover the structure of this elusive molecule, told in two interlocking stories. One is a quest of fundamental biology to decipher the structure of the ribosome and show how it functions. This is no idle quest: the ribosome is the target of many major antibiotics, and its structure promises new treatments against deadly infections. The other story is the personal one, a portrait of scientists as human beings, driven as much by rivalry as by the desire to uncover nature's secrets. Ultimately, Gene Machine shows not just what it takes to win a Nobel Prize, but also reveals that who you know and how you handle them are just as important to scientific success as are brains, luck, and hard work. As riveting as it is refreshingly honest, Gene Machine is a story of ambition, achievement, and human frailty in pursuit of high-stakes science"--Jacket.… (más)
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Talks about how the structure of the ribosome was "solved". It also discusses scientific competition and awards. ( )
  Castinet | Dec 11, 2022 |
Look I don't like biology and I enjoyed this book. The author walks a fine line between modesty and self-promotion, but hey as a Nobel prize winner, I guess a little bragging is warranted. Worth the read. ( )
  Skybalon | Mar 19, 2020 |
What an interesting little book! I have to say, I never thought I'd read a book that centered so much around the ribosome, but my high school biology teacher would be proud. Ramakrishnan's life and story gripped me from the start and he did well incorporating both science and memoir into his novel.

I received an advanced copy through Netgalley in return for an honest review. ( )
  Kristymk18 | Jan 30, 2019 |
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"The co-recipient of the 2009 Nobel Prize in Chemistry discusses his critical research on the ribosome, a molecular machine that actually forces DNA into action, turning genetic code into functioning proteins that create life"--Source of summary not specified. "Everyone has heard of DNA--the molecule that seems to hold the secrets to all life. But by itself, DNA is little more than a blueprint for life, resting inertly within our cells. Hardly anyone, however, has heard of a ribosome. Ribosomes are enormous molecular machines, even more ancient than DNA, that translate the information in our genes into proteins. Those proteins in turn make up much of our bodies and catalyze thousands of processes within our cells. A ribosome, in short, is a machine no cell can do without. And until quite recently, how that machine worked was a mystery. Gene Machine is an insider account of the Nobel Prize--winning race to uncover the structure of this elusive molecule, told in two interlocking stories. One is a quest of fundamental biology to decipher the structure of the ribosome and show how it functions. This is no idle quest: the ribosome is the target of many major antibiotics, and its structure promises new treatments against deadly infections. The other story is the personal one, a portrait of scientists as human beings, driven as much by rivalry as by the desire to uncover nature's secrets. Ultimately, Gene Machine shows not just what it takes to win a Nobel Prize, but also reveals that who you know and how you handle them are just as important to scientific success as are brains, luck, and hard work. As riveting as it is refreshingly honest, Gene Machine is a story of ambition, achievement, and human frailty in pursuit of high-stakes science"--Jacket.

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