Cyrus The Talking Chimpanzee escapes from Bob The Scientist and his assistant Janet and sets forth on a journey across America: traveling carnivals, circus sideshows and tent revivals. Along the way Cyrus is picked up by The Colonel and his motor home stuffed with dusty jars full of shrunken heads and pickled Siamese twins. While watching television Cyrus finds religion and decides to become a televangelist. Two crooked television producers, Jackie Bob and Bobby Jack, put Cyrus on the air and soon the money comes rolling in. Cyrus must try to break free from his televangelist handlers after he becomes convinced that Jesus Christ has returned- as a spider monkey.