From Botswana and sub-Saharan Africa to Thailand, Romania, and Brazil, an exploration of developing countries with limited access to healthcare and scarce resources reveals how such factors as tourism, international travel, war, and mobility have facilitated the insidious spread of HIV and AIDS. Candid discussions of sensitive issues such as stigma and its effects on morale and health complement scientific and medical inquiries into the origins of the disease and the development of antiretroviral therapies. An analysis of groundbreaking solutions such as "medication adherence partners," prevention strategies, and current vaccine models adds a glimmer of hope to a seemingly hopeless crisis.