The systems in which we work continue to evolve, creating emergent problems and often strengthening intractable issues. In order to remain relevant and impactful, the discipline of ergonomics needs its paradigms to evolve too. The aim of this book is to provide researchers and practitioners with new paradigms in the form of ideas, concepts, theories, methods, practices and values. The chapters take the reader on a journey through underlying theories, new ways to apply those theories and emerging domains in which ergonomics is expected to play a greater role. Readers of this book will be inspired by these new paradigms in ergonomics and seek to push the boundaries even further. The lifeblood of the science depends on continual evolvement and developments to take on the challenges we face in complex sociotechnical systems design and evaluation. Perhaps the most significant take-home message from this book is the demonstration of how theory maps onto practice. As such, the only remaining paradigm shift is for these ideas, concepts, methods and practices to be taken up more widely and the discipline advanced, until the next paradigm shift occurs. The chapters were originally published as a special issue in the journal Ergonomics.