Topics in Handbook of Adolescent Medicine, 2nd Edition, include adolescent health statistics, biologic and psychosocial growth and development, the adolescent office visit, endocrine/metabolic, gynecology, contraception, infectious diseases, cardio respiratory, genitourinary, dermatology, musculoskeletal and sports medicine, mental health and psychotropic medications, nutrition, rheumatology, and miscellaneous clinical conditions. This issue of Adolescent Medicine: State of the Art Reviews is a stand-alone reference and practice tool with evidence-based reviews that detail advances in the diagnosis and management of a wide range of health problems affecting adolescents.