Bo and Rico are two puppies who meet at a pet store. The puppies are dognapped from the pet store by two goons. Realizing they are in danger, Bo and Rico must work together to escape the dognappers. After their escape, Bo and Rico find themselves scared and alone on the mean city streets. They are rescued by a streetwise stray named Tank. Tank takes the puppies under his wing and teaches them how to survive on the streets. Bo and Rico embark on several adventures including avoiding the local Animal Control officer, Jimmy; several run-ins with a pack of dogs led by a stray named Mongrel; and rescuing a beautiful lost Poodle named Pearl. Through it all, Bo and Rico form an incredible friendship that will last a lifetime.