When still in high school, the Amazing Spider-Man faced one of his most chilling challenges when six of his most nerve-wracking nemeses formed a cabal of crime: the Sinister Six! Years later, Doctor Octopus reunites the team for his most remarkable racket yet, and time has made them deadlier than ever - even as it's made Spidey's life more complicated than ever! Can he teach the Six a lesson, or will they school him instead? Plus: the fate of a longtime Spidey supporting character and of Mary Jane's greatest enemy! Guest-starring the Fantastic Four, the Avengers, and more! Collects Amazing Spider-Man Annual (1964) #1, and Amazing Spider-Man #334-339.