The House of Guise was one of the greatest princely families of the sixteenth century, or indeed of any age. Today they are best remembered through the tragic life of one family member, Mary Queen of Scots. But the story of her Guise uncles, aunts and cousins is if anything more gripping - and certainly of greater significance in the history of Europe. The Guise family rose to prominence as the greatest enemy of the House of Habsburg and had dreams of a great dynastic empire that included the British Isles and southern Italy. They were among the staunchest opponents of the Reformation, played