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How to Clone a Mammoth: The Science of De-Extinction (2015)

por Beth Shapiro

Otros autores: Ver la sección otros autores.

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"Could extinct species like mammoths and passenger pigeons be brought back to life? The science says yes. In [this book], Beth Shapiro, evolutionary biologist and pioneer in 'ancient DNA' research, walks readers through the astonishing and controversial process of de-extinction. From deciding which species should be restored, to sequencing their genomes, to anticipating how revived populations might be overseen in the wild, Shapiro vividly explores the extraordinary cutting-edge science that is being used--today--to resurrect the past"--Amazon.com.… (más)
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I don’t want to make anybody nervous, but the story of how I bought this book by the scientist of Bethany is, that first I bought a science book by what in the 21st century we might call a gentleman scientist, and then I went digging through my notes app and transferred a book title from there to my Amazon Saved For Later titles (limit 600 items, plus it gets more and more cumbersome the more you add to it, but I wanted to add some science books to my history books and other snobby humanities—snobby religion and snobby art; science can be snobby too, but people look up to it, and it’s different), and so then that book was also by a gentleman scientist, (like, he was Louis Vuitton, not Coco Chanel, lol), and so, I thought, well one of these books came from something called the Princeton Science Library, so I Amazon searched that, and, in what I guess was a short span of geological time, but an annoying amount of scrolling time, was able to scroll to a science book by a lady scientist, the scientist of Bethany here. So, one day, I’ll buy this book, and the other book, (one of them is already on the way, that third one), and then, bam! Knowledges! Ok! 🤯 👩

…. I bought the book! I started it!

Ok, first, I didn’t expect this to be something that was feasible, like, this year, you know. And obviously, if we could clone the mammoth but there was no home for it, no ecosystem, you know—what’s the point? I mean, the megafauna extinctions were probably caused by //ancient, Native// populations, you know. If the Eskimos or whoever caused too much disruption by bringing one down with spears every other year or something, Putin drilling for oil in Siberia and random Russians with assault rifles is going to be a bit of a problem, right.

That said, I don’t know why you call a book “how to clone a mammoth” if you don’t think that cloning large extinct animals isn’t a possibility in the long-range future, like 100 or 200 years, assuming we’ve gotten our ecological act together and society votes or whatever that, we need mammoths!, you know. But like, “How to clone a mammoth”: chapter one, Cloning extinct animals is impossible, and will always be impossible. Chapter two…. ~I mean, it’s weird, right.

I mean, I’m going to read the book, so it’s fine I guess. I guess the bottom line is that we have a lot of power and are gaining more, including the power to theoretically be less disruptive to nature and become more viable long-term, all of which are good things…. But we basically don’t know how to use the power we already have all that well, which is a bummer. We still have to try, I guess; that’s not what I mean, but…. Given just our computer skills we could probably program Earth to be paradise in 200 years and I guess maybe we will but, I don’t know, right. You have a nice spiritual exercise and you’re sure the bright future’s going to happen; you reflect that we don’t want scientists to be women half the time, or often for women to be able to do anything, or how scientists often can’t use normal verbal language all that well, or how nobody ever seems to respect other disciplines, or how religion and politics are going from bad to yup, still bad, and it’s like…. You know forget about the mammoth; I’m just going to call the mother. Get her to protect me. Leave paradise for the people not yet born to bet on what year we solve for P where P = paradise, you know. But, hey.

…. Yes, the book is about bringing back extinct species—make a note to experiment different clunky ways of saying that, while becoming extremely intolerant of my own kookiness—but, rest assured, I will not be positive, and you won’t have to feel good. Happiness CAN be avoided, thank the Spaghetti Monster. But this curious strange exercise might still leave you with the sneaking suspicion that you’re better than other people, and that’s good…. Just remember you’re not better than me….

There was a time when I was too much a scholar to read the competing scholarships, you know; but I think my days of Kumbaya we’re all scholars are probably ending….

—I don’t want to understand ~things~, I want to understand the ~words~ by which things are called.
—Right. I mean, you’re almost right. But really you should understand ~numbers~, not the things numbered.
—Huh. So we have a disagreement!
—So we do!
—There are two ways of looking at the world!

…. (smiles)

I mean, I am glad that there’s science. Without science, (in our non-Indigenous, non-magical consensus), we would have nothing, basically, not purely human, nothing not derived from human history, and perhaps philosophy, but mostly custom and precedent, in whatever form…. And again, nothing about the custom and precedent of the other forms of life….

But scientists are strange people, you know. I realize as a (as I’ve since become) sorta crazy Merlin person, I’m throwing stones, he whose walls are made of glass, but…. I mean, scientists are our cultural ideal, to some extent, at least they’re the cultural ideal we own up to, but, WOW—strange!!

…. And it can be funny watching scientists trying to make decisions without emotions (!), or philosophy (neither one? 😹), or any sort of decision-making system; like, I’m waiting for some Indian nation in Brazil to say, We want you to bring back our god (so-and-so) whom you know as the (so-so-bird) and the Wiccans will be like, Yes! It’s Brigid!! (or whoever), and the scientists will be like, Silence, children! I SAID SILENCE, CHILDREN!! ~~😹😹

…. But whatever. It’s fine. It’ll be ok.

…. I know that I sound sarcastic or whatever, and then suddenly pollyanna-y, and that the latter probably irritates some scientists almost as much as criticism. But what I mean is, many of the dysfunctions in the typical member of the scientific community owe a lot to the problems of the larger parent society, you know. The scientific heritage and thought reform process at its best does have the ability to improve society.

…. One of the things that I got is that time doesn’t ever go back exactly: the more time passes, the greater the chance that we’ll have to let that organism go, wholly or at least in part. It might be possible to create hybrid types with living species, or certainly to learn more about the path that biological evolution took. But the more time passes, the more the remains decay and the planet moves on.

But I was impressed by—and I do not mean this as an insult; I mean it well—the secular “ritual” of science, the special, “ritual” action of experiments and other laboratory [or field expedition] actions. Unlike in I guess you could say modern philosophy, and most forms of philosophy that people call as such, and theology, if that word can be applied exactly, in science ~action~ matters….

Maybe not ~quite~ as much as in purely practical books and studies, but still. And yet the most important thing is to allow there to be a harmonious human population (and not a miserable but too-weak-to-do-major-damage human population of the past) to share the planet with the other organisms and allow them to evolve again, whether or not any particular form is reproduced or not. And the most relevant things for that are probably snarky youth-centric Gen Z publications that poke the Millennials in the gut with a long stick, right—that or just prosperity books so I can afford organic, responsible-agriculture products, for example, and electric cars, and so on…. The way that I didn’t understand when I was dancing because I was 22, you know.

But I digress. I respect the informations.

…. Stereotypically I’m the one to doubt the doubters, but I think in their own process it can be well. They say, I don’t know we can do this; I don’t know that we can do that—and it sounds to me like they can’t even try, usually, for the tropical species that die and rot in an hour or whatever. And I don’t even care about the mammoth. (Sorry, Canada/Alaska.)

This might come across as an insult to Dawkie and Friends, but I feel like it’s easier now to accept ‘settle down children’ science criticism when I see that doubt is part of their own system, you know.

…. I guess I didn’t realize that selective breeding can work faster than I thought—more like historical time, a few or a handful of centuries, rather than real-long ~geologic~ time, if you can decide what you want and stick with it. It just kinda raises the question of what people want it for, when it’s become a success, and how patient they want to be with it, I guess.

As for using a computer to construct a genome, (a species’ gene pool), I’m not opposed to this, not in any sort of energetic way, or offended way, but I’m skeptical that it would work in any meaningful way in the near future. I don’t think our computers are advanced enough, and I don’t think that our consensus philosophy or whatever you want to call it that scientists use, generally, (and there would be Controversy! if they didn’t), really understands or rather makes space for the mystery of life enough to create meaningful or lasting results. You can work on it and try to evolve the computers for it if you have the money, but in terms of evolving actual literal squishy (carbon) life, I don’t know. I don’t know that there’s any shame in creating life and having it frown a lot and die—it’s no different than what some teenagers, indeed, really, most or at least, many many people do. And I don’t believe in shaming people. But if you don’t understand what god/spirit/Life-Principle is in the arctic duck you’re weaving, how do you really get a sense of what you’re creating? How do you decide that you created the life-principle you wanted to create? How do you know what you want, right?…. “Well, I want real hairy, because…. I don’t know. I want to see a hairy duck.” It just doesn’t seem, oddly, that the stakes for success are that high. It just doesn’t seem like it would be as successful as a natural-birth animal, and it probably wouldn’t be successful even in the physical way, I would bet. But whatever. These are the times we live in, right.

…. I mean, I feel like the ancient Jews were too perfectionist in copying the Bible and destroying it if there was one typo; however, a person is like a sacred book, you know, or an organism, and I feel like a scientists are trying to copy a sacred book by learning the alphabet but not knowing what the words mean, you know.

(shrugs) Or maybe I’m just crazy. That would certainly be a simpler conclusion to come to, right. 😸

…. Ok, so maybe it can be more about what resurrecting old-duck-like ducks can be like for the lake, rather than this superficial quasi-romantic improbable thing, right. “Just because they’re ducks! 100% Old Duck stock!”

It basically could be selective breeding on steroids. That’s probably the future. Maybe one day we’ll have elections over rival plans for duck DNA, or ads about the same from the relevant capital-raising campaigns that get on the Super Bowl, you know.

Or the…. Pickleball Championships. (Future!)

…. Actual campaign ad: If trans/queer kids don’t get burned at the stake by their parents, white women whose brains have been burned out by their husbands will rebel! No persecution no peace! No persecution no peace! I can’t hear you, mothers!

~ Whoops, hey we’re not there yet!….

Seriously, though, why do mothers have to be an embarrassment to the community? “You think I like being a mother? You think I like being treated like brain dead garbage Every, Day? The only reason I signed up for this is because I figure I can be the thought police, like the crippled persecutor, you know. First you play dead…. Then you attack! Hey, look! A happy woman! Let’s tie her down and dishonor the wench! Mothers, move out!

“Ah-ha. Americans.”

Oh my god, they’re dishonoring our community. It’s so sad…. I like it here. I used to like it here, couple of minutes ago. I don’t have any jobs or housing agreements lined up anywhere else….

(white woman) This year, I’m voting for the Nazis. It has nothing to do with race: I need to hurt my children. (awkward smile!)….

[…. Offended Woman: I mean, first I agree to surrender my full humanity and my completeness and become miserable for the Greater Good, and then! and then people don’t compensate me by Never Disliking Me No Matter What, because you have to do it my way because I stabbed myself in the gut for you. This would Never have happened under King Arthur! This November, vote Gwenhwyfar/Arthur on the Persecute Pagans Party. This message has been paid for Village Customs Group Choice—Capitalism, Eh! “I’m Gwenhwyfar and I’m a better person than you are. So die, scum!”]

[…. I mean, the Christians have the perfect scam; they really do. First, you take all that traditional oppression of women, take away whatever sexual or religious or professional competency is left, turn codependency into the only permissible morality, and voila! You have a feminine zombie army that will support the male elite, far more so than most random groups of men, you know. (chuckles) The only thing you forgot is an honest reward for your damages minions, you know! Well, no plan is perfect. I’m sure everyone will respect them, though. (chuckles) Perhaps the whole fingers crossed behind your back is an old biblical sign of respect, you know.]

I mean, if they wanted to nurture someone, you’d think they’d want to nurture the whores—probably the most un-nurtured, damaged, and traumatized group out there, or damn near. But I guess if you’re doing it all by yourself, you can’t take on those tough assignments, right. Instead you say: (talking into phone) 10AM re-traumatized whore, saw her successfully excluded from the group. Repeat: successfully traumatized whore; successfully traumatized whore. Blue eagle. Red 52. The fisherman found the purple hat, over. (looks around) What are You looking at?

…. Anyway.

Re: captive animals hurting themselves/animal dysfunction

I always disagreed with those mystics & romantics who say, We suck; animals are great, right. Animals are like us, they’re not better than us or worse. The more I hear about animals the more I think that it’s possible for an animal to be dysfunctional, you know. Some of them can also be almost as intelligent as a very small child, or at least a baby, right.

…. (end) And yes, if you’re curious, I happened to have changed my religious affiliation in between the time that I wrote the pre-review, and finished the book. (During which time I was probably in between on maybe a hundred books, or whatever, and occasionally even real life. 😸). I guess sometimes even a god can’t be a success if his friends betray him after he’s gone. Although I’d like to think that I wasn’t that traitor. 😉

…. (now it’s over) Anyway, it suddenly occurs to me that this isn’t natural history; it’s general biology/ecology, you know…. And, yes, I make fun of science nerds and scholars, but I sorta get that it’s hard to try to deal with the public’s attention span and not have them grossly misunderstand things, you know.

I’m not even gonna make a joke about that. Can’t even go there. 😸

…. Ok, I’ll make a joke about hate mail: “I learned that I was going to bring about the end of the world.”

Well, at least you learned! 😹

The electorate is so educated—and kind—right! 🥳

No worries. Just say mahalo. Mahalo, Great Spirit, that you have made us great. 😗

…. (NOW it’s over) Probably the worst enemy of applied ecology is recentism. Nature moves slowly. She’s patient. Native humans weren’t perfect at land management, but they weren’t recentist. They didn’t watch TV poorly; they didn’t even write angry little papers in journals, you know. One day, we’ll incorporate and improve upon the old Native secrets. We’re not there yet.
  goosecap | Oct 30, 2023 |
Really a 3.5.

This book has a lot of good information in it. Shapiro is very practical and up front about the current state of the art regarding bringing extinct species back to life. She does not stop there, but also discusses the political aspects as well as the larger practical aspect: what are the larger goals, is there an appropriate environment to which the de-extincted creature be re-introduced (de-unintroduced?).

The writing is somewhat uneven and didn't grab me. It's not a page turner. Some things get repeated more than they need be - while on the other hand some more technical aspects or terms are glossed over. If you know or remember some biology, it's not a problem. For example, I'm guessing that most readers would appreciate terms like prokaryotic and eukaryotic being clearly defined, even if one can infer their meanings from context.

So, a strong recommendation to anyone with an interest in the topic, particularly because the book is current and keeps things real. Otherwise, you may want to pass on this one.
( )
  qaphsiel | Feb 20, 2023 |
What a fascinating and thought-provoking book. It covers the science, technology, ethics, and (many!) difficulties of the process of de-extinction. It's a few years old now, but I think very relevant. Highly recommended for anyone interested in the ideas of ecosystem revival, genetic manipulation, and of course conservation. ( )
  SChant | Jun 9, 2020 |
How to Clone a Mammoth: The Science of De-Extinction is a book that explains the science behind the de-extinction process and the methodology behind cloning extinct organisms. This is the only book that I have managed to find so far that covers the science of the process and doesn't just discuss all the ethical aspects of this technology. The authorbriefly mentions the ethics, economics, uses and socio-political aspects of de-extinction technology, but this is covered in more detail in the excellent book [b:Resurrection Science: Conservation, De-extinction and the Precarious Future of Wild Things|23848047|Resurrection Science Conservation, De-extinction and the Precarious Future of Wild Things|M.R. O'Connor|https://d2arxad8u2l0g7.cloudfront.net/books/1430945113s/23848047.jpg|43458049]. Resurrection Science and How to Clone a Mammoth compliment each other nicely, and cover the subject in detail up to this point in time.

In this book, Shapiro discusses the purpose of de-extinction and the controversy surrounding this new technology. She also discusses the factors involved in selecting a suitable species for de-extinction; how to find a well preserved specimen so that useful ancient DNA can be obtained, why amber is not a good source of ancient DNA; genome recreation and modification; how to create a clone and the challenges that are encountered with this process; making more of the cloned species; setting the de-extinct population free; and finally, if we should do such a thing.

The book explains the science very well - providing enough details so the reader knows what is going on, but not providing so many minutiae that the reader becomes lost. The author, however, tends to repeat information but the repetitiveness wasn't too annoying. Shapiro is involved with mammoth and dodo de-extinction research, so this book tends to focus on these creatures. However, exciting research and anecdotes from other scientists is also included.

I believe the author has nicely explained her aim in writing this book, namely to provide a road map for de-extinction, beginning with how to decide what species/trait to resurrect, traveling through the circuitous and often confusing path from DNA sequence to living organism, and ending with a discussion about how to manage populations of engineered individuals once they are released into the wild. Shapiro's goal was to explain de-extinction in a way that separates the science form the science-fiction. The author also states that she believes in many cases, de-extinction is scientifically and ethically unjustified. But, she also believes that de-extinction technology has great potential to become an important tool for conserving species and habitats that are currently threatened.

I found this book enjoyable to read and managed to learn a few things in the process. The author also leaves the reader with something to think about.

( )
  ElentarriLT | Mar 24, 2020 |
This is a very interesting subject and very rigorously and thoroughly presented. It makes a case for de-extinction and presents the science behind it as of today diving into the significant complexity of this enterprise in a clear and objective analysis of the issues raised by the possibility of de-extinction. Two main criticisms: The first being that the title has been sexed up to sell more books. As Prof Shapiro makes clear, cloning a mammoth is not ever actually going to happen. The best that can be done is to create a genetically engineered elephant with some mammoth characteristics. The second criticism relates to the inconclusiveness inherent in writing a book on a subject that is developing so quickly. It doesn't quite leave things on a cliff edge but it's not far off and it would be nice to have a subscription channel to keep up with what happens next. ( )
  Philogos | Mar 30, 2019 |
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Nombre del autorRolTipo de autor¿Obra?Estado
Beth Shapiroautor principaltodas las edicionescalculado
Alejandro, JasonDiseñador de cubiertaautor secundarioalgunas edicionesconfirmado

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For my children, James and Henry, who will inherit whatever mess we make.
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The first use of “de-extinction” was, as far as I can recall, in science fiction.  (Prologue)
A few years ago, a colleague of mine practically bit my head off for getting the end date of the Cretaceous period wrong by a little bit.
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The first use of “de-extinction” was, as far as I can recall, in science fiction.  In his 1979 book The Source of Magic, Piers Anthony describes a magician who finds himself in the prescence of cats, which, until that moment, he had believed to be an extinct species.  Anthony writes “[The magician] just stood there and stared at this abrupt de-extinction, unable to form a durable opinion.'  I imagine that this is precisely how many of us might react to our first encounter with a living version of something we thought was extinct.  (Prologue, p. ix)
The year 2013 saw “de-extinction” become its own branch of science, at least accotding to the Times.    Despite this lofty status, there is as yet no consensus as to what the goal of de-extinction science is.  At first it seems obvious.  De-extinction aims to resurrect, via cloning, identical copies of extinct species.  For species that have been extinct for a long time, however – the passenger pigeon, the dodo, the mammoth – cloning is not a viable option.  In the case of these species, de-extinction will have to mean something else.  Most likely, it will mean that specific traits and behaviors of the extinct species will be genetically engineered into living species.  The living species will than gain the adaptations necessary to thrive where the extinct species once did.  Will society, however, respond favorably to de-extinction if the goal is not to bring back an actual mammoth, dodo, or passenger pigeon?  (Prologue, p. x)
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"Could extinct species like mammoths and passenger pigeons be brought back to life? The science says yes. In [this book], Beth Shapiro, evolutionary biologist and pioneer in 'ancient DNA' research, walks readers through the astonishing and controversial process of de-extinction. From deciding which species should be restored, to sequencing their genomes, to anticipating how revived populations might be overseen in the wild, Shapiro vividly explores the extraordinary cutting-edge science that is being used--today--to resurrect the past"--Amazon.com.

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