George's Grandma is a grizzly, grumpy, selfish old woman with pale brown teeth and a small puckered up mouth like a dog's bottom. Four times a day she takes a large spoonful of medicine, but it doesn't seem to do her any good. She's always just as poisonous after she's taken it as she was before. When George is left to look after her one morning, it's just the chance he needs .

Roald Dahl, como siempre siempre se gana mi diez. ( )

Jorge, empeñado en cambiar a su desagradable abuela, inventa una maravillosa medicina con la que consigue transformarla. Pero nada resulta como Jorge esperaba. Los animales de la granja también toman la medicina... y las situaciones más disparatadas no se hacen esperar.