Three years after the sudden, mysterious death of their 1-year-old daughter Lily, Josef Coleman, a high-strung New York surgeon, and his editor wife Claudia Macinnes remain mired in anguish and grief. Their mourning has left them reaching out for different things in different ways: Josef for a primal, physical connection that Claudia can no longer bear, and Claudia for a connection of the soul that Josef has never really known how to offer. To numb his pain and attempt to fill the gaping hole of loss, Josef turns to a young surgical nurse named Kiera; Claudia, meanwhile, is drawn into what seems like an unrequited fantasy about her psychotherapist, Stuart. The time she spends in his office -- this sole "other room" where she can allow herself to project into the future-- becomes a rare bright spot in her weeks. The couple's extended families soon become implicated in the unraveling of their lives. Bit by bit, haunting pasts and their impact on the present are revealed, as is the chilling truth about Lily's death. Interwoven with Claudia's meticulous journal entries offering glimpses of a sunnier future, the story ultimately takes a surprising turn reaffirming that in tragedy's wake lie redemption, reckoning and peace.