This postgraduate reference reviews the pathogenesis and clinical features of a disease that is of particular interest to adult and paediatric gastroenterologists and clinical immunologists. This multi-author text covers gluten-sensitivity in its widest context: overt coeliac disease, dermatitis herpetiformis, and manifestations in family groups. Discussion of pathogenesis includes the role of gluten and other environmental factors, cell-mediated and humoral immunity, and molecular genetics. At the clinical level the efficacy and discriminatory powers of diagnostic tests in distinguishing different types of tolerance and sensitivity are reviewed.